Objectives: To examine the effect of rehabilitation technology interventions on the employment or job retention outcomes of individuals with multiple sclerosis (MS) served by the state-federal vocational rehabilitation program using a case-control study design. Participants: Data for this study were extracted from the Rehabilitation Services Administration Case Service Report database. The sample included 8,715 individuals with MS aged between 16 and 64 years old whose cases were closed between the fiscal years of 2007 and 2011. Outcome measure: Competitive employment. Results: The classification and regression tree method identified 5 homogeneous subgroups ranging from high to low propensity to receive rehabilitation technology services. Specifically, individuals with MS employed at application were most likely to receive rehabilitation technology intervention. The effect of rehabilitation technology on job retention was especially strong for individuals aged 35 years or older with a college education. Conclusion: These findings suggest that rehabilitation technology is an effective service for enhancing job retention outcomes of middle-aged and older adults with MS and provide valuable information for policymakers, health care providers, rehabilitation counselors, and educators.