The Mid-South Region of Alabama, Arkansas, Louisiana, and Mississippi as a long history of pervasive poverty and educational underachievement. According to the U.S. Census Bureau (2008), the poverty level of residents in the Mid-South Region is higher than the national average. Consequently, many of the region's best and brightest students of all ages seek education as a way to leave their communities for perceived economic opportunities outside of the region. The resulting brain drain impacts the region's economic viability due to the less-skilled workforce that is left behind. Similarly, many of the most capable future business owners leave the region, reducing the viability of business development. The region mirrors the rest of the United Stated with its significant declines in manufacturing since 1990. Bureau of Labor Statistics (2008) data show that 16 percent of the country's workforce was employed in manufacturing in 1990, but by 2007 that figure was only 10 percent. In 2007, the Trent Lott National Center for Excellence in Economic Development and Entrepreneurship (Lott Center) at the University of Southern Mississippi created the Southern Entrepreneurship Program (SEP). The SEP teaches program participants entrepreneurial skills, financial literacy, networking, and business plan development. This program was piloted in four high schools and at Pearl River Community College in Mississippi during 2007 and 2008. This report describes how the program works and the outcomes. (Contains 1 table.)