The origin of the Science-Humanities Program (NEXA) at San Francisco State University, California, is described. The overall goal of NEXA was to provide a model for reconciliation between the two cultures, science and humanities (philosophy, literature, history, and the arts). The first objective was to establish a sense of collegiality and common purpose among the faculty of these fields. A second objective was to derive its new curriculum. Beginning with a core of 10 courses, this curriculum has enlarged to 20 courses taught by humanist-scientist teams. These courses are designed to provide basic concepts, historical perspectives, and acquaintance with current issues involving mutually the sciences and the humanities. The NEXA curriculum may be used by students to satisfy general education and elective requirements or to serve as the basis of major or minor programs. Additionally, a special master's curriculum is available for qualified students. The third objective of NEXA was to offer public events of high interest that brought to focus concerns shared by humanists and scientists, and the fourth was to disseminate the idea of science-humanities cooperation throughout a 19-campus system by means of consultations, conferences, and workshops. A historical summary is presented of the so-called "two-cultures" dilemma, whose origins are traced to the 17th century and whose consequences for the 19th and 20th century experience are examined in detail. Specific attention is paid to the new field of sociobiology as an example of scientific reductionism. The present plight of the humanists, the role of logical positivism, and possible future alternatives for a rehumanized philosophy are also examined. Another area of concern is "the new humanities." (SW)