Because the transition to a knowledge-based economy requires an educated workforce, colleges and universities have made retention of students--particularly those who are academically underprepared--an institutional priority. College completion leads to economic and social advancement for students and is also critical to the nation's economic and social strength. To increase student success, the University of Wisconsin-Milwaukee (UWM) implemented the technology-enabled U-Pace instructional approach in Introduction to Psychology, a course that most students take during their college career. Extensive evaluation in Introduction to Psychology courses indicates that U-Pace instruction--which combines self-paced, mastery-based learning with instructor-initiated Amplified Assistance in an online learning environment--facilitates greater learning and greater academic success for "all" students compared to conventional, face-to-face instruction. (Contains 5 figures and 2 endnotes.)