ERIC Number: EJ767935
Record Type: Journal
Publication Date: 2004-Sep
Pages: 4
Abstractor: Author
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: N/A
Postextinction Infusion of a Mitogen-Activated Protein Kinase Inhibitor into the Medial Prefrontal Cortex Impairs Memory of the Extinction of Conditioned Fear
Hugues, Sandrine; Deschaux, Olivier; Garcia, Rene
Learning & Memory, v11 n5 p540-543 Sep 2004
We investigated whether postextinction training infusion of PD098059, a selective inhibitor of mitogen-activated protein kinase (MAPK) activation, into the medial prefrontal cortex, would impair retention of extinction learning in rats. We found that immediate, but not late (2 or 4 h), postextinction infusion of PD098059 provoked a full return of conditioned freezing. These results suggest that activation of prefrontal MAPK in early stages of postextinction training participates in processes that protect against spontaneous recovery of aversive responses. (Contains 2 figures.)
Descriptors: Brain, Memory, Fear, Conditioning, Retention (Psychology), Animals, Drug Use, Biochemistry, Learning Processes, Responses
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A