Ethical growth and prosocial development are increasingly salient learning outcomes in higher education. Previous research has shown that the traditional college years facilitate moral development, especially with respect to moral reasoning. This research examined the impact of college experiences on students' sense of active responsibility for others--prosocial orientation--via a longitudinal, multi-institutional design through the Spirituality and Higher Education project at University of California, Los Angeles. Data from over 14,000 undergraduates show that key college experiences predict growth on prosocial outcomes. Especially salient predictors include active forms of learning, engagement with diversity and other means by which students encounter multiple perspectives. Implications for higher education are discussed.