With recent attention to improving scientific workforce development and student achievement, there has been a rise in effort to understand and encourage student engagement in physical science. This study examines the association of family influence and initial interest in science through multiple and logistic regression models. Research questions addressed include Controlling for demographic variables, are physical science doctoral students or scientists who report family as a primary source of interest in science, as opposed to those that do not, more likely to develop an early interest in science? And what specific forms of family support are associated with doctoral students or scientists who report family as a primary source of initial interest in science? The study uses survey data from Project Crossover ("n" = 4,285), a sequential mixed methods study that examines factors influencing entrance into physical science doctoral programs as well as the transition from graduate students to independent researcher. Results suggest that family interest in science facilitates earlier initial interest in science. Further analyses show that family influence shifts from parental occupation as the primary source of interest for the older generation of scientists to one of three influences (occupation, diversion or hobby, and encouragement) among doctoral students. (Contains 2 tables.)