This study examined a full path model of stress process for predicting illicit drug use among Asian and Latino immigrants' adolescent children. Using 2-year longitudinal data (National Longitudinal Study of Adolescent Health) from a sample of adolescents with Asian or Latino immigrant parents (N = 2,353), the study explored structural relationships between 3 types of negative perceptions of school environment as acculturation-related stressors (a feeling of isolation, perceived prejudice from students, and perceived unfair treatment from teachers), family support as a social resource, and drug use as an outcome among Asian and Latino immigrants' adolescent children. Path analysis results supported the resource deterioration hypothesis of the stress process model and found a stronger direct effect of implicit isolation than explicit prejudice or unfairness perceived in school on drug use and mediating effects of family support on relationships between 2 of the stressors and drug use among these adolescents. (Contains 2 tables and 2 figures.)