Continued efforts are needed to reduce teenage pregnancy in the United States. Implementation of evidence-based curricula in schools is one strategy toward meeting this goal. In 2010, the South Carolina Campaign to Prevent Teen Pregnancy (SC Campaign) received funding to implement a teen pregnancy prevention (TPP) curriculum. Congruent with South Carolina law, the curriculum had to be approved by a school district advisory committee. A case study was conducted to explore factors that led to adoption of the curriculum in one school district. In-depth interviews (n = 17) were conducted with school district staff, advisory committee members, community stakeholders, and SC Campaign staff. An inductive analysis identified several key themes that promoted curriculum adoption: developing networks among TPP advocates, partnerships with local media, establishing a school district commitment to address TPP, assembling a diverse advisory committee, a comprehensive curriculum approval process, and utilizing the expertise of the SC Campaign. TPP curriculum adoption may be facilitated through advocacy efforts, community and school partnerships, and the implementation of a comprehensive approval process that considers multiple stakeholders including parents, school administrators, students, and faith community leaders.