We investigated executive functioning in 25 children and adolescents with Prader-Willi syndrome (PWS) on the Behavior Rating Inventory of Executive Function (BRIEF). Significant deficits emerged, with mean scores on all but two scales reaching levels of clinical significance (T score = 65). Older children tended to have higher scores than younger children. Children with uniparental disomy demonstrated higher scores than children with deletion and were more likely than children with deletion to have ratings in the clinically significant range on two scales. The PWS BRIEF profile resembles that of children with autism and intellectual disability from previous studies. Results are discussed in the context of intervention development.