Low-income mothers in the U.S. are more likely to experience postpartum depression (PPD) and less likely to seek treatment than their middle-class counterparts. Despite this knowledge, prior research has not provided an in-depth understanding of PPD symptoms as they are experienced by low-income mothers. Through in-depth interviews, this study investigated low-income mothers' (n = 19) experiences and explanatory frameworks for their PPD symptoms. Grounded theory analysis uncovered five main categories that linked the participants' PPD symptoms to their lived experiences of mothering in poverty, including: (1) ambivalence, (2) caregiving overload, (3) juggling, (4) mothering alone, and (5) real-life worry. The analysis further located the core experience of PPD for low-income mothers as "feeling overwhelmed" due to mothering in materially and socially stressful conditions. These findings challenge the prevailing biomedical discourse surrounding PPD and situate mothers' symptoms in the context of the material hardships associated with living in poverty.