ERIC Number: EJ991619
Record Type: Journal
Publication Date: 2012-Nov
Pages: 11
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1087-0547
EISSN: N/A
A Randomized, Double-Blind, Crossover Comparison of MK-0929 and Placebo in the Treatment of Adults with ADHD
Rivkin, Anna; Alexander, Robert C.; Knighton, Jennifer; Hutson, Pete H.; Wang, Xiaojing J.; Snavely, Duane B.; Rosah, Thomas; Watt, Alan P.; Reimherr, Fred W.; Adler, Lenard A.
Journal of Attention Disorders, v16 n8 p664-674 Nov 2012
Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted in adults with primary ADHD. The primary end point was changed from baseline in total score on the Adult ADHD Investigator Symptom Rating Scale following a 4-week treatment regimen. Additional measures included Clinical Global Impression--Severity Scale, Hospital Anxiety and Depression Scale, and Brown Attention Deficit Disorder Scale and D4 genotype analysis. Results: No statistically significant treatment differences were found between MK-0929 and placebo in any of the primary or secondary assessments. Conclusion: Results from this study suggest that blockade of the D4 receptor alone is not efficacious in the treatment of adult ADHD. (Contains 3 tables and 2 figures.)
Descriptors: Rating Scales, Depression (Psychology), Attention Deficit Hyperactivity Disorder, Genetics, Role, Adults, Symptoms (Individual Disorders), Severity (of Disability), Measures (Individuals), Scores, Therapy, Etiology, Drug Therapy, Outcomes of Treatment, Comparative Analysis
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A