Early establishment of physiological societies in Oklahoma and Ohio demonstrated the benefits of networking physiologists and paved the way for establishing the APS Chapter Program. Designed to promote the general objectives of the APS, the Chapter Program was officially launched in 1995, with Ohio being the first recognized chapter. There are 13 active chapters regularly engaged in numerous activities designed to advance physiology education and research. In the hopes that others will recognize the important offerings of state chapters and consider organizing one, the aims for this paper are to 1) share a brief history, 2) provide rationale for chapter initiation, and 3) describe the process involved in establishing a chapter. In light of current changes in American Medical Association and Liaison Committee on Medical Education guidelines, the present time may be critical in promoting chapters, as they play.