As defined in the Individuals with Disabilities Education Improvement Act, occupational and physical therapists provide services to support students to access, participate, and progress in their educational program within the least restrictive educational environment. Educationally relevant occupational and physical therapy services in school settings is characterized by its unique focus on the early identification of and intervention for students in need of learning, behavioral and functional supports to maximize skills that enable lifestyle sustainability and community participation after high school. In this commentary, the authors share their perspectives on educationally relevant occupational and physical therapy practice and address the challenging issues of understanding the nature of educationally relevant service, developing student-centered education and learning communities, determining need, establishing goals, strategies, and supports, lifespan considerations, and facilitating active student engagement. The authors believe the therapists have an opportunity to serve as change agents in their school districts by implementing best practices that support students with disabilities to access and participate effectively in school activities of choice and to benefit from learning opportunities. (Contains 2 figures.)