This study examined the association among personality traits, life events and life satisfaction, and the underlying pathways from personality traits to life satisfaction. A total of 1,961 adolescents were recruited from 21 secondary schools in Hong Kong. The adolescent version of the Chinese Personality Assessment Inventory (CPAI-A), the Chinese Adolescent Life Events Checklist (CALEC) and the Satisfaction With Life Scale (SWLS) were employed to assess their personality, life events and life satisfaction, respectively. Multiple regression analysis showed there was an additional value of the indigenously derived scales of CPAI-A, including the Family Orientation, Harmony and Ren-Qing scales, in predicting life satisfaction beyond the universal personality traits. Results also indicated that there was a partial mediation effect of negative life events on personality traits in the prediction of life satisfaction.