Validity and reliability of Persian adaptation of MSLSS in the 12-18 years, middle and high school students (430 students in grades 6-12 in Bushehr port, Iran) using confirmatory factor analysis by means of LISREL statistical package were checked. Internal consistency reliability estimates (Cronbach's coefficient [alpha]) were all above the conventional criterion of 0.70 for all factors indicating adequate reliability of the factors. Cronbach's coefficient [alpha] of the total scale was 0.83. The pattern matrix appeared by and large to be consistent with previous investigations of the MSLSS using exploratory factor analytic methods. It seems this Persian adaptation of the MSLSS offers a reliable and valid means of assessing Iranian middle and high school students' life satisfaction. Using that as a screening tool in schools may help in discriminating between different domains responsible for child and youth problems.