This three-part guide presents information and recommendations from the Massachusetts Professional Development School Network Steering Committee on how to develop a professional development school (PDS) partnership. Part 1 defines the PDS concept, presents a brief background account of its evolution, and discusses its potential for simultaneously improving teaching and learning through the transformation of school and college structures and practices. Part 2 identifies five principles and characteristics of PDSs. Comments from teachers, interns, and college faculty involved in PDS partnerships supplement this discussion. Part 3 offers practical advice, in a question and answer format, on how to form and sustain a PDS. Answers to the following questions are given: (1) Why start a PDS? (2) Who will initiate the partnership? (3) How do schools and colleges find partners? (4) How are partnerships defined and developed? and (5) How do you organize and run a PDS partnership? Concrete examples from within Massachusetts illustrate specific approaches to start-up problems and challenges. This guide includes contact information for members of the Massachusetts Professional Development School Network Steering Committee. (Contains 13 references.) (IAH)