One of the biggest challenges for practitioners is implementing a new program or a new practice. This challenge is due, in large part, to a lack of information on strategies that promote effective and efficient program implementation. In most cases, implementation strategies have been limited to paper-based manuals that focus on describing interventions without providing complementary information on necessary implementation resources and activities. Because of this, they do not facilitate the real-world application of innovative, research-based practice. Recently, researchers have begun to study implementation in an effort to understand the key ingredients for successful program implementation. This brief will define implementation, highlight why the effective implementation of evidence-based practices is critical to achieving outcomes, and outline six core components that drive successful program implementation, referred to as "drivers." (Contains 11 notes.) [This publication was sponsored by The Atlantic Philanthropies.]