Perhaps one of the fastest ways to improve the quality of out-of-school time programs would be to replace practices that individuals know do not work with practices that appear to be more effective. In this brief, the authors highlight lessons from an expanding body of knowledge about specific program practices that should be avoided or minimized in out-of-school time programs to improve their chances of success. In a related brief, they highlight 10 practices to foster. (Contains 1 footnote.)