The purpose of this study was to examine the use of word prediction software to increase typing speed and decrease spelling errors for students who have physical disabilities that affect hand use. Student perceptions regarding the effectiveness of word prediction was examined as well as their typing rates and spelling accuracy. Four students with physical disabilities were selected for this study. Criteria for participation included: (a) having a physical disability with fine motor problems, (b) meeting the Georgia requirements for orthopedic impairments (i.e., students with physical disabilities having mild intellectual disabilities or above), (c) receiving services through an orthopedic impairments special education program, (d) being high school age, (e) having utilized word processing for a minimum of two years, (f) having a below average handwriting rate, typing rate, and/or making spelling errors on over 5% of their work (either due to motoric or learning issues), (g) having had no formal instruction of the use of word prediction software, and (h) having had prior experience with accessing a computer (either with standard keyboard or alternate access devices). In this study, the dependent variables were typing rate and percentage of spelling errors. The independent variable was the use of word prediction software. The data from this study indicated that there can be potential benefits of word prediction software for some individuals with physical disabilities that affect hand use. Two out of four students are continuing into their second year of using word prediction for their primary means of independent work output. If word prediction software improves motivation to type, decreases spelling errors, increases typing rate, or reduces fatigue, it can be a valuable tool for individuals with physical disabilities.