Recruiting research samples within vulnerable populations can be challenging, especially due to geographic dispersal and the services accessed, as well as hesitation related to legal status and stigma. Public health, however, requires sustained recruitment efforts. We describe challenges and solutions in recruiting urban adolescent Latinas who had attempted suicide. Procedures for recruitment and human subject protections were established, yet logistic obstacles emerged. Program directors failed to support the research; therapists were slow to identify subjects and to meet inclusionary criteria; numbers of prospective participants were lower than originally calculated; girls and parents were hard to reach; and interview appointments were missed. From challenges came solutions: to use fewer agencies, do better participant surveillance, monitor staff participation, and build rapport and relationships with staff. In-service research training to develop agency research infrastructure generated support among providers and administrators. Our experience may be helpful to other researchers conducting studies with similar populations. (Contains 1 note.)