ERIC Number: EJ853497
Record Type: Journal
Publication Date: 2009-Sep
Pages: 3
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: N/A
A Green Multicomponent Reaction for the Organic Chemistry Laboratory: The Aqueous Passerini Reaction
Hooper, Matthew M.; DeBoef, Brenton
Journal of Chemical Education, v86 n9 p1077-1079 Sep 2009
Water is the ideal green solvent for organic reactions. However, most organic molecules are insoluble in it. Herein, we report a laboratory module that takes advantage of this property. The Passerini reaction, a three-component coupling involving an isocyanide, aldehyde, and carboxylic acid, typically requires [similar to] 24 h reaction times in organic solvents, but produces a quantitative conversion and yield in less than 30 min when performed in water. This rate enhancement allows the Passerini reaction to be easily adapted for use in a second-year organic laboratory course. Additionally, the incorporation of this laboratory module facilitates discussions of both green chemistry and combinatorial chemistry in the curriculum. (Contains 2 schemes and 2 notes.)
Descriptors: Organic Chemistry, Science Experiments, Science Laboratories, Science Instruction, Scientific Principles, Water, Molecular Structure, College Science, Teaching Methods
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://www.jce.divched.org
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A