We report the student response to a two-year transformation of a one-semester organic chemistry course for nonchemistry majors. The transformed course adopted a peer led team learning approach and incorporated case studies. Student attitudes toward the course transformation were assessed throughout the semester, and adjustments to the methods were made in response to student surveys. No change in student performance on exams was observed compared to a traditional lecture course. However, significant improvements in the end of course "Student Assessment of Instruction" were recorded.