Virtual gaming has taken the world by storm and is being used by a much larger population than originally anticipated. Since the Wii was put on the market, occupational therapists around the world have begun to incorporate its use as an intervention strategy for patients recovering from a wide scope of ailments. This use is ad hoc, intuitive, and idiosyncratic on the part of individual occupational therapists. Little research has been done to investigate the factors influencing occupational therapists' acceptance and use of virtual gaming as an intervention strategy to enhance the occupational performance of their older adult clients. This study investigated the appropriateness of using the Unified Theory of Acceptance and Use of Technology (UTAUT) (Venkatesh et al., 2003) to explain occupational therapist's acceptance and use of off-the-shelf virtual gaming as an intervention strategy with their older adult clients. Data from 516 occupational therapists who were members of the American Occupational Therapy Association, selected gerontology as a primary interest selection, and reported spending at least 50% of their time working with older adult clients were used for analysis in this study. An online questionnaire was used to assess occupational therapists' acceptance and use behaviors. A higher-order confirmatory factor analysis was performed to confirm the factor structures and model for behavioral intention and use. The results confirmed that performance expectancy, attitude, and social influence significantly contribute to occupational therapists' behavioral intention to use off-the-shelf virtual gaming as an intervention strategy with older adults in occupational therapy. Effort expectancy, self-efficacy, and anxiety did not contribute to behavioral intention. The results also found that facilitating conditions did not contribute significantly to use behavior. The research model explained 83% of the variance in behavioral intention in behavioral intention and 30% of the variance in use behavior. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]