With the development of Information Technology, increasing attention has been paid to Computer Assisted Language Learning (CALL). Meanwhile, increasing enthusiasm is seen for English learning and teaching in China. Yet, few research studies have focused on the normalization of CALL in ethnically diverse areas. In response to this research gap, this study aims to identify major factors affecting the normalization of CALL in Chinese senior high schools in the Qian Xi'nan Buyi and Miao Autonomous Prefecture (QBMP). A questionnaire was administered to 340 English teachers and a semi-structured oral interview was conducted as a follow-up. The study produced the following four findings: (a) most teachers were in favor of using computers in English teaching although they had to be cautious in guiding students; (b) institutional support was seen as instrumental; (c) teachers' computer competency and relevant training were considered to be important; and (d) teaching methodology and learner factors were identified as crucial.