The latest researches adopted software technology to improve pointing performance; however, Drag-and-Drop (DnD) operation is also commonly used in modern GUI programming. This study evaluated whether two children with developmental disabilities would be able to improve their DnD performance, through an Automatic DnD Assistive Program (ADnDAP). At first, both participants had their baseline sessions. Then the first participant entered into intervention. New intervention began with the second participant when his performance was consolidated. Finally, maintenance phase occurred with both participants, in which their DnD performance improved significantly. Data showed that both participants improved their DnD efficiency with the assistance of ADnDAP, and remained highly successful through maintenance phase. Implications of the findings are discussed. (Contains 7 figures.)