Purpose: The purpose of this paper is to explain, in the context of the massification and internationalisation of higher education, how Web 2.0 and its socially oriented knowledge system (episteme) has the potential to counter the current neo-colonial disprivileging of non-mainstream knowledge systems and discourses. Design/methodology/approach: The paper, drawing on postcolonial, epistemological, and Web 2.0 learning literatures, first deconstructs the continued dominance of the traditional academic discourse in transcultural settings. It then illustrates how Web 2.0's non-foundational approach to the nature of knowledge gives it the capacity to construct postcolonial transcultural learning zones that are inherently open to other knowledge systems and discourses. Findings: The paper concludes that the socially oriented knowledge system or episteme of Web 2.0 enables educators to create postcolonial, meaning more epistemically inclusive, transcultural learning zones in which no one knowledge system or discourse is automatically privileged. Practical implications: The paper highlights the role Web 2.0 can play in negating the colonialising impact of dominant educational practices that disprivilege non mainstream knowledge systems and discourses that have entered university learning environments through massification and internationalisation. Originality/value: The paper addresses a significant gap in the literature by highlighting the pivotal but much neglected role of epistemology in Web 2.0 as well as in the internationalisation and massification of higher education. More specifically, it indicates how the respectful acceptance of different knowledge systems and discourses can create postcolonial architectures of learning and promote a more egalitarian form of cosmopolitanism.