Strong societal requirements and consumer acceptance are the driving force of nanotechnology development. The necessity for qualified experts and strong demand on education in the multi-, trans- and interdisciplinary field of nanotechnology is a logical consequence of this driving force. There is the need for a comprehensive national skill-needs-identification study as a first step towards developing the appropriate workforce and to prevent any skill gap or shortage. This paper provides an analytical overview of skill needs and human resources development for the emerging fields of nanotechnology and gives recommendations for further research. Emphasis is placed on the role of vocational educational training (VET) in skill development for nanotechnology. Evidence review and secondary analysis of the literature are used as the methodological approach. A comparative analysis of approaches to nanotechnology workforce development in Germany and the United States is done.