Hemispheric laterality may be a useful concept in teaching, learning, training, and in understanding more about human development. To address this issue, a measure of hemispheric laterality was compared to musical and mathematical ability. The Human Information Processing Survey (HIPS) instrument, designed to measure hemispheric laterality, was administered to 101 participants who were then asked to provide a measure of their conceptual aptitude for mathematics and music. Scores were then compared through canonical correlation to test the hypothesis that perceived mathematical ability may be explained by left-brain hemisphere preference and musical by the right hemisphere. A relatively strong correlation was found between music ability and right-brain hemisphere preference. A relationship between math and left-brain hemisphere preference or integrated brain processing scores was found to be marginal. Ramifications to learning are discussed.