The study was designed to determine how standard science skill builder activities can be modified or adapted for use by orthopedically handicapped students. Nine secondary level science experiments were selected for initial review and from these, three were selected for adaptation--use of the microscope, use of graduated cylinders, and use of the balance. Each of the activities were modified in terms of three levels of involvement of orthopedically handicapped: mildly involved--defined as ambulatory with or without assistance, use of one or both hands, can be an active participant in the experiment; moderately involved--confined to a wheelchair, use of one or both hands, may have muscular dysfunction, may have a moderate degree of participation and may need some assistance in the experiment; and severely involved--confined to a wheelchair, minimal use of hands and a high probability of being a passive participant in the experiment. As each skill builder activity was conducted as it would be in an average secondary school, task analyses were conducted to identify possible problems that might occur when the activities are being performed by orthopedically handicapped learners. (The revisions of the adapted skill builder activities appear in their final form in the last section of the document with sections on use of each instrument, preskills needed, expected outcome, experimental steps, adaptations needed for each level of involvement, major equipment modification, and demonstration of learning.) (SBH)