The need exists for educational methods which can positively influence self-esteem, especially in demanding military healthcare settings. Warrior Transition Units (WTU's) are tasked with the challenging mission of caring for seriously injured or ill U.S. Army Soldiers. This paper explored the hypothesis that an educationally-based Mental Skills Training (MST) intervention can enhance self-esteem in members of a Warrior Transition Unit in the U.S. Army. The sample was comprised of 27 WTU cadre members who participated in an Army Center for Enhanced Performance (ACEP) MST educational workshop at a large Army installation on the West Coast. Instruments included the Ottawa Mental Skills Inventory (OMSAT-3; Durand-Bush & Salmela, 2001) and the Self-Esteem Rating Scale (SERS; Wagnild, 1993). Results showed that SERS scores were significantly higher following the intervention. Furthermore, the ACEP instructional components of self-confidence, imagery, and mental practice were significant predictors of self-esteem. Results suggest that MST might be a viable educational approach for enhancing self-esteem in the WTU cadre. (Contains 1 table.)