Provided is a collection of papers on computer literacy and simulation originally published in The Physiology Teacher, supplemented by additional papers and a glossary of terms relevant to the field. The 12 papers are presented in five sections. An affirmation of conventional physiology laboratory exercises, coping with computer terminology, and an overview of computer hardware are considered in the three papers in section 1 (introduction). A primer on computer technology and discussion of the analog computer as a physiology adjunct are presented in the two papers in section 2. A single paper in section 3 focuses on the rationale for and resources utilized in teaching computer literacy and physiological simulation, and includes descriptions of simulation programs. State of the art with regard to physiological simulation is considered in the five papers presented in section 4. Topics/areas addressed include carbon dioxide control in respiratory systems simulation, teaching simulation with microcomputers, computer model of cardiovascular system for effective learning, computer simulation in the student laboratory, and digital computer simulation of cardiovascular and renal physiology. Advantages and limitations of physiological simulation are considered in the final paper presented in section 5. (JN)