Teachers in the US have been increasingly adopting mobile devices for teaching, but little research has examined how pre-service teachers perceive mobile device integration in classrooms. To address this issue, the study developed a research model that explained factors affecting pre-service teachers' intention to use mobile devices and the relationship among the factors. A total of 386 pre-service teachers participated in an online survey, and the model was tested using structural equation modeling. The results showed that 72.5% of variances in pre-service teachers' intention to use mobile devices were explained by perceived usefulness and self-efficacy for technology integration jointly, where perceived usefulness was the strongest predictor. The findings also demonstrated that constructivist beliefs and perceived ease of use indirectly influenced pre-service teachers' intention to use mobile devices for teaching.