In this study (N = 137), although 70.8% of participants reported no current substance use and 42.3% reported never using, the Adolescent Substance Abuse Subtle Screening Inventory (SASSI-A2; Miller & Lazowski, 2001) screened 39.41% of the participants for a high level of probability of having a substance-related disorder. SASSI-A2 classified more females in our sample as having a high probability of substance-related disorder than males. Among African American participants, male adolescents had substantially higher levels of drug use and significantly lower levels of alcohol use than did female adolescents. Implications, limitations, and future directions are provided. (Contains 3 tables.)