ERIC Number: EJ918279
Record Type: Journal
Publication Date: 2010-Jun
Pages: 3
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: N/A
Microwave-Assisted Hydantoins Synthesis on Solid Support
Coursindel, Thibault; Martinez, Jean; Parrot, Isabelle
Journal of Chemical Education, v87 n6 p640-642 Jun 2010
In this laboratory activity, students are introduced to a three-step synthesis of hydantoin (imidazolidine-2,4-dione), a moiety that is found in many biologically active compounds. Using a microwave oven and solid-support technology, this synthetic experiment is designed for masters-degree candidates working in organic chemistry or upper-level undergraduate chemistry students interested in solid-phase synthesis. A colorimetric test is used to monitor the reaction on the solid support and analytical techniques such as high-pressure liquid chromatography, mass spectrometry, and nuclear magnetic resonance are used to assess the product purity and yield. (Contains 1 table, 1 figure and 2 schemes.)
Descriptors: Organic Chemistry, Science Instruction, Science Laboratories, Biology, Heat, College Science, Undergraduate Study, Scientific Principles, Spectroscopy, Diagnostic Tests, Graduate Study
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A