Purpose: The purpose of this study was to determine the best practice strategies, those that bring the most value for the twice-exceptional (2e) student (giftedness with autism spectrum disorder [ASD], attention deficit hyperactivity disorder [ADHD], specific learning disabilities [SLD], and/or emotional and behavioral disorder [EBD]) in the general education classroom in 2020, as determined by an expert panel composed of academics and practitioners using a Delphi study. A secondary purpose was to determine the feasibility of the best practices identified by the experts, or the ease with which they can be implemented in the classroom. Methodology: An expert panel of academics and practitioners determined most effective and most feasible best practice strategies for 2e students in the general education classroom in 2020 using a three-round Delphi method to obtain consensus from the experts. Findings: Both groups determined accommodating and modifying instruction using strengths and weaknesses and assessment for strengths and weaknesses were the most effective and most feasible best practice strategies. The expert praxis group ranked the strategy of differentiating for instruction and grouping as effective and the most feasible best practice. Both groups identified independent study contracts as one of the least effective best practice strategies and the least feasible to implement. The academic group identified allowing 2e students to help other students as the least effective best practice strategy. Overall, the two groups did not agree on most rankings. Conclusions: Making accommodations and modifications for 2e students using their strengths and weaknesses, assessing for strengths and weaknesses, and differentiating instruction and grouping students are strong best practice strategies. Assessing 2e students for strengths and weaknesses and making accommodations and modifications using their strengths are easily implemented in the classroom, as are differentiating instruction and grouping students, teaching 2e students organizational skills, and providing students with immediate feedback. Placing students on independent study contracts is not as effective and is difficult to implement. Recommendations: Future researchers should consider recruiting urban teachers from a major city to serve as expert panelists, recruiting teachers and academics of either highly gifted or underachieving gifted students for their suggested strategies. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]