This article outlines the U.S. Army's effort to empirically validate and assess the Comprehensive Soldier Fitness (CSF) program. The empirical assessment includes four major components. First, the CSF scientific staff is currently conducting a longitudinal study to determine if the Master Resilience Training program and the Comprehensive Resilience Modules lead to lasting resilience development in soldiers. Second, the CSF program has partnered with other researchers to conduct a series of longitudinal studies examining the link between physiological, neurobiological, and psychological resilience factors. Third, the CSF program is also incorporating institutional-level data to determine if its material influences health, behavioral, and career outcomes. Fourth, group randomized trials are being conducted to ensure that resilience training incorporated under the CSF program is effective with soldiers. A specific rationale and methodologies are discussed.