First-generation Latino youths and their families may encounter significant challenges as they experience changes in their culture after migrating to a new country. Some Latino youths enter the United States having experienced trauma through premigration, migration, and postmigration stages of their transition. Many symptoms and behaviors associated with their traumatic experiences will emerge in schools, directing first-generation Latino youths into the mental health system. Identifying factors that mitigate the intensity of these symptoms are critical for youths' adjustment. This article describes a study that examined the relationship between various factors that promote psychological and social well-being among a sample (N = 56) of first-generation Latino youths in an English as a Second Language school. Findings indicate that emotional regulation and social integration negatively relate, whereas environmental mastery positively relates, to posttraumatic stress disorder symptoms among Latino youths.