This manual is intended for administrators and professional caregivers who wish to provide comprehensive health care to children with Human Immunodeficiency Virus (HIV) infection, the cause of Acquired Immune Deficiency Syndrome (AIDS). Chapter 1, an overview, examines the societal and economic issues that affect care and treatment of children infected with HIV. Chapter 2 describes five key components of pediatric HIV/AIDS programs: long-term planning for chronic illness; child-centered and family-focused approach; interdisciplinary, collaborative care; case management; and community support. Chapter 3, "Mobilizing for Program Organization," is a step-by-step guide to establishing a program of care through assessment, planning, implementation, and evaluation. Chapter 4 provides extended descriptions of the 10 hospital pediatric HIV/AIDS programs throughout the country from which information was gathered to produce this manual. Appended are the following resources: (1) official definitions and classifications of HIV-related diseases; (2) community assessment guide; (3) a list of state AIDS coordinators; (4) an outline of critical program components through the continuum of care; (5) a list of resources for service providers including AIDS clinical trial units, demonstration projects, organizations, audiovisuals, literature, and telephone contacts; and (6) a listing of the 10 highlighted programs. (TE)