We present a simplified human alcohol metabolism model for a mass balance team project. Students explore aspects of engineering in biotechnology: designing/modeling biological systems, testing the design/model, evaluating new conditions, and exploring cutting-edge "lab-on-a-chip" research. This project highlights chemical engineering's impact on biotechnology and human health and promotes advanced analysis of results, develops engineering judgment, spotlights current biotechnology research, and illustrates scaling down. Pedagogical aspects, including teaching points, career interest, and student feedback, are discussed.