Loneliness is a universal phenomenon, and its pain is intensified by a diagnosis of a terminal illness. The present study is an investigation of the strategies used by patients with Multiple sclerosis (MS), by individuals diagnosed with cancer, and by the general population to cope with loneliness. Three hundred and twenty nine MS patients, 315 cancer patients, and 391 participants from the general population answered a 34-item questionnaire. Results indicated that with the exception of Reflection and acceptance, Distancing and denial, and Increased activity, the three groups cope with loneliness significantly differently.