This article introduces the Kuder Skills Assessment-College and Adult version (KSA-CA; Rottinghaus, 2006), a new measure incorporating advances in the measurement of self-efficacy across 16 basic occupational domains (e.g., finance, information technology) and the six Kuder Clusters. Similar to the original development sample, all scales of the KSA-CA were highly internally consistent, and demonstrated expected gender differences and relations with each other in a sample of 241 business students from a large Midwestern university. Of the 198 participants who had selected a specific business major, four specialty areas were identified: accounting, management, finance, and marketing. Mean KSA-CA scores were examined between the development and business samples and among the specialty groups. The business sample scored higher than the development sample across nine domains, including all with business-related content. Several relevant scales distinguished subgroups of business majors supporting the validity of the specialized KSA-CA scales. (Contains 5 tables and 1 figure.)