The purpose of this study is to determine the effects of gender differences and levels of loneliness on ways of coping. The sample of the study is composed of 462 university students (245 male, 217 female) from different departments from the Education Faculty at Cukurova University. In this study to collect data related to loneliness as an independent variable, the UCLA Loneliness scale was used and to collect data related to ways of coping as a dependent variable, the BriefWays of Coping Inventory was used. Multivariate Analysis of Variance (MANOVA) was applied to data. The findings indicated that there were significant differences in ways of coping according to gender (male/female) and levels of loneliness (low/high). The main effect of gender indicated that male students use self confident, optimistic, and hopeless ways of coping more than female students. Thus, the socialization theory related to gender and coping was supported in Turkish context. In addition the main effect of loneliness indicated that students who have a low level of loneliness use self confident, optimistic, and social support seeking ways of coping more than those who have a high level of loneliness. As a conclusion, gender and the level of loneliness have significant effects on ways of coping. The findings were interpreted in accordance with the existing literature on gender, loneliness, and coping.