A growing body of research indicates that lesbian, gay, bisexual, and transgender (LGBT) students are often unsafe at school. Little research has examined school safety for students with LGBT parents. We examined adolescents' perceptions of school safety for students with LGBT parents using data from a survey of 2,302 California sixth through twelfth grade students. We examined the influence of adolescents' personal characteristics and school environments on perceptions of school safety for students with LGBT parents. Compared to heterosexual students, adolescents who identified as LGBT were less likely to perceive their schools as safe for students with LGBT parents. Students who received education on LGBT issues knew where to get information about LGBT issues and had teachers that step in to prevent harassment were more likely to say that their schools were safe for students with LGBT parents. Implications for educational policy and practice are discussed. (Contains 2 tables.)