School leadership, head teacher professional development and school management practices in sub-Saharan Africa have varied little from the model of schooling established during colonial rule. Leadership for Learning (LfL) is a programme of school leadership developed at the University of Cambridge over a period of 10 years in conjunction with an international group of researchers and practitioners. This paper reports the results from questionnaire data gathered from a cohort of 125 head teachers who participated in the LfL programme in Ghana between 2009 and 2011, and speculates on the successes and barriers to leadership and learning. Implications arising from the scaling up of the LfL programme to include all Ghanaian schools are discussed.