The use of accommodations has been widely proposed as a means of including English language learners (ELLs) or limited English proficient (LEP) students in state and districtwide assessments. However, very little experimental research has been done on specific accommodations to determine whether these pose a threat to score comparability. This study examined the effects of linguistic simplification of 4th- and 6th-grade science test items on a state assessment. At each grade level, 4 experimental 10-item testlets were included on operational forms of a statewide science assessment. Two testlets contained regular field-test items, but in a linguistically simplified condition. The testlets were randomly assigned to LEP and non-LEP students through the spiraling of test booklets. For non-LEP students, in 4 t-test analyses of the differences in means for each corresponding testlet, 3 of the mean score comparisons were not significantly different, and the 4th showed the regular version to be slightly easier than the simplified version. Analysis of variance (ANOVA), followed by pairwise comparisons of the testlets, showed no significant differences in the scores of non-LEP students across the 2 item types. Among the 40 items administered in both regular and simplified format, item difficulty did not vary consistently in favor of either format. Qualitative analyses of items that displayed significant differences in p values were not informative, because the differences were typically very small. For LEP students, there was 1 significant difference in student means, and it favored the regular version. However, because the study was conducted in a state with a small number of LEP students, the analyses of LEP student responses lacked statistical power. The results of this study show that linguistic simplification is not helpful to monolingual English-speaking students who receive the accommodation. Therefore, the results provide evidence that linguistic simplification is not a threat to the comparability of scores of LEP and monolingual English-speaking students when offered as an accommodation to LEP students. The study findings may also have implications for the use of linguistic simplification accommodations in science assessments in other states and in content areas other than science.