In order to integrate library instruction seamlessly into an introductory biology course, two librarians collaborated with a biology faculty member to create a three-part series of instruction sessions known as the Science Seeker. The Science Seeker taught students about the structure of scientific information by tracing the path that discoveries take from the laboratory to the textbook. By using concepts from the course, students learned about biology while simultaneously learning information literacy skills as a central communication skill for scientists. This article describes the planning, execution, and evaluation of this unique approach to course-based library instruction for science majors. (Contains 2 tables.)