The Department for Children, Schools and Families (DCSF) has contracted with the Learning and Skills Network to support awareness and take-up of Triple Science GCSEs through the Triple Science Support Programme. This publication provides an introduction to teaching and learning approaches for the extension topics within GCSE Chemistry. It highlights some specific ideas that teachers can adopt and where to find further information. It also outlines issues for managing the change. This guide contains seven sections: Section 1 presents the policy context; Section 2 describes this publication; Section 3 outlines how Science, Additional Science and Extension Science (Chemistry) are structured and the related Annex 1 compares the chemistry content for each specification, outlining what is required for Science, Additional Science and Extension Science; Section 4 outlines effective teaching and learning approaches relevant to the extension topics in GCSE Chemistry; Section 5 provides specific ideas for teaching and learning the key topics in the extension specifications; Section 6 outlines issues to consider when implementing GCSE Chemistry in a science department, such as staffing, continuing professional development, health and safety, and resource requirements; and Section 7 lists resources and organisations from where further information can be obtained. Annexes include (1) GCSE Chemistry specifications at a glance; (2) Teaching and learning models: bibliography and further reading; (3) Assessment of How Science Works in different GCSE Science courses; (4) LSN science publications; and (5) LSN science publications. (Contains 13 figures.)