Sharing thoughts on what represents significant advancements involving the education of persons for whom typical instruction is not effective seems simple enough. You think about the work you are engaged in and reflect on how you came to do what you are doing. If you have a record of being persistent in your work, then that becomes the context for your perceptions of significant advancements. While limited as a strategy for framing a vision for the future, the views of an individual do have potential when combined with the perspective of others. Emerging technologies in the realm of instructional change brought about by the Internet provide the framework for the choice of significant advancements, discussed in this article, to improve instruction for all students including students with disabilities. They include the impact of technologies that allow for measuring physiological and motivational responses of online learners that enhance the personalization of online instruction, the impact of wireless computing in contributing to how ubiquitous computing influences learning environments for all learners, and the increased capacity offered by technology to increase sensitivity to variability among online learners and to stimulate research in the important area of inquiry.