Aspiring to become an international city in Asia, the government of the Hong Kong Special Administrative Region (HKSAR) has been investing more in higher education. In order to enhance its global competitiveness, all public universities in Hong Kong have gone through different forms of quality assurance exercises, including teaching and learning processes reviews, research assessment exercises, management and governance reviews, as well as quality assurance council reviews. In the context of the significant emphasis placed by Hong Kong on the internationalization of higher education, this article examines the major approaches and strategies that the HKSAR has adopted in enhancing quality in teaching, learning, and research in higher education, and also discusses the major challenges for quality assurance confronted by the city-state.